Weight Management in Basal-Bolus Insulin Therapy for Type 2 Diabetes Mellitus: The Deep South Diabetes Program

JosAnn Duane, PhD and William Conway, MD

Weight gain is considered to be a standard clinical complication of insulin therapy. This complication bears heavily on patient populations at risk for obesity, such as those in the southeastern United States. This study was designed to evaluate the weight changes associated with intensive basal-bolus insulin therapy in the Deep South Diabetes Program. Effectiveness was assessed by evaluating the relationship between changes in glycosylated hemoglobin (A1C) and changes in body weight that occurred during therapy.