Insulin Journal Supplement

A Meeting of the Minds

Steven V. Edelman, MD, and Derek LeRoith, MD, PhD, Editors

Diabetes and the metabolic syndrome are reaching epidemic proportions in the United States and in many countries around the world. Among the most devastating complications...

Preface: Hyperglycemia, Cardiovascular Disease, and Hospitalized Patient Outcomes

Richard W. Nesto, MD

Hyperglycemia at the time of hospital admission is a significant predictor of increased mortality among patients with acute myocardial infarction (AMI).

Impact of Hyperglycemia on Inpatient Outcomes: A Therapeutic Target?

Richard W. Nesto, MD

Patient survival after acute myocardial infarction (AMI) has improved considerably during the last several decades as percutaneous coronary intervention (PCI), fibrinolytic therapy, and other advances have entered clinical practice.

Anti-inflammatory and Antiatherogenic Effects of Insulin

Paresh Dandona, BSc, MD, DPhil, Ajay Chaudhuri, MD

Recent clinical and experimental studies have shown that chronic vascular inflammation is an important contributor to the development of atherosclerosis.

An Endocrinologist point of View on the Practical Use of Insulin

Irl B. Hirsch, MD

The use of sliding-scale SC insulin for glycemic control in hospitalized patients with diabetes mellitus can produce clinically important fluctuations in blood glucose concentrations over time.

Rationale for Glycemic Control in Cardiac Surgical Patients: The Portland Diabetic Project

Anthony P. Furnary, MD

Since 1987, the Portland Diabetic Project has enrolled >5000 patients with diabetes mellitus (DM)-including patients with noninsulin-dependent DM and patients with insulin-dependent DM-in a prospective nonrandomized study of the effects of perioperative insulin administration on morbidity and mortality after open-heart surgical procedures.