Insulin Journal
VOLUME 2, NUMBER 1

Editorial

Editorial

Since publication of our last issue of Insulin, the American Diabetes Association Scientific Sessions were held in San Francisco, California. The results of 3 landmark studies (Action in Diabetes and Vascular Disease [ADVANCE], Action to Control Cardiovascular Risk in Diabetes [ACCORD], and Veterans Affairs Diabetes Trial [VADT]) were revealed, all of which focused on the role of glucose control and its influence on macrovascular disease in type 2 diabetes mellitus (DM). Although all 3 studies concluded that tight glucose control did not significantly reduce major coronary events, they reminded us about the importance of treating our patients individually and as safely as possible. The bottom line is to diagnose early, initiate treatment for glucose and cardiovascular risk factors in a timely manner, and avoid hypoglycemia and excessive weight gain.

In this issue of Insulin, we address several important issues as they relate to the management of patients with DM, using an individualized approach to reduce not only the long-term macrovascular and microvascular complications of DM, but also the forgotten acute conditions that affect morbidity and mortality. Inpatient management of patients with DM has been one of the age-old problems of diabetes care and has become an important treatment issue.

Tight glycemic control was accepted as the standard of care even before publication of the Diabetes Control and Complications Trial (DCCT) because of the strong outcomes data collected from the infants of mothers with DM with varying degrees of control. Now that more women with type 2 DM are becoming pregnant, identification of the causes of pregnancy loss in this growing segment of our population is becoming increasingly important.

We also look at the influence of endothelial dysfunction, vascular inflammation, and oxidative stress on the complications of DM. Correction of these well-documented abnormalities to normal or near-normal levels is believed to be very important in stabilizing the internal metabolic and vascular milieu to minimize acute and chronic complications.

We carefully plan the issues of Insulin to address not only topics on clinical management but also important scientific information as it becomes available. It is hoped that these articles are helpful to you, the readers of Insulin—health care professionals working at multiple levels to improve the management of patients with DM—as they relate to your understanding of the disease and its complications. We hope you enjoy this issue.

 

Articles in This Issue

Physicians' Corner: The Good Old Days Were Not So Good for Inpatient Care
Charles F. Shaefer, Jr., MD, FACP, FCCP

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Diabetic Retinopathy: Unraveling the Paradoxical Effects of Intensive Insulin Treatment
Jorge L. Jacot, PhD, Aaron I. Vinik, MD, PhD

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Acute Glycemic Control in Hospitalized Patients: Evidence Published Since the American College of Endocrinology Position Statement
Zachary Bloomgarden, MD, Jeffrey I. Mechanick, MD

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The Impact of Diabetes Education on Improving Patient Outcomes
Lisa Kiblinger, RN, MS, CDE, Norbert L. Braza, MS

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Weight Gain and Management Concerns in Patients on Insulin Therapy
Sydney A. Westphal, MD, Pasquale J. Palumbo, MD, MACP, MACE

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Insulin Therapy: The Question This Issue
Anuj Bhargava, MD, MBA, CDE, FACP, FACE

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Response to Previous Case Study
Derek LeRoith, MD, PhD

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Patient Handouts

Staying Healthy to Avoid Illness

When you have diabetes, managing your blood glucose and taking care of your health may help you avoid serious illness and a trip to the hospital. Staying as healthy as you can requires regular planning and maintenance.

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All articles have been reviewed by members of our Editorial Board or independent referees.

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